Putative sequence of Abeta(1-42) M35L
Notes about the sequence of the Luhrs-Riek construct.
10 20 30 40 50 60
MRGSHHHHHH GSNANPNANP NANPNANPNA NPNANPNANP NANPNANPNA NPNANPNANP
70 80 90 100 110 120
NANPNANPNA NPNANPNANP NANPNANPRS MDAEFRHDSG YEVHHQKLVF FAEDVGSNKG
130
AIIGLLVGGV VIA
Parameters computed by ExPASy Protparam:
Number of amino acids: 133
Molecular weight: 13800.6
Theoretical pI: 6.74
Ext. coefficient: 1490 M-1 cm-1, at 280 nm
Full sequence without the numbering:
MRGSHHHHHHGSNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPRSMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLLVGGVVIA'
This is the non-Abeta leader from the above sequence:
MRGSHHHHHHGSNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPRSM
These are 19 NANP repeats.